RPE65 and retinal degeneration: Consistent with the phenotype observed in the cohort of patients analyzed in this study, the RPE65, LCA5, USH2A, CNGB1, FAM161A, CERKL and GUCY2D genes consisting mutations in 13 of the 26 pedigrees have been implicated in causing recessive non-syndromic retinal degeneration [1].