Recent research has demonstrated that glomerular Angptl4 secreted by podocytes is upregulated in experimental MCD and membranous nephropathy (MN) rats, and research has shown that Angptl4-transgenic rats exhibit high levels of proteinuria, thus indicating that glomerular Angptl4 mediates proteinuria in some types of glomerulonephropathy[10]. This evidence concerns the gene ANGPTL4 and membranous glomerulonephritis.