CLEC7A and psychiatric disorder: Indeed, through functional studies in mice and genetic association studies in human, the authors demonstrated that: i) The susceptibility to severe colitis is genetically driven; (ii) Deficiency of Dectine-1 in mice and human cells promotes fungal infection; (iii) Induced colitis in CLEC7A knockout mice results in anti-Saccharomyces cerevisiae antibody production, the latter often observed in schizophrenia, another major psychiatric disorder; iv) In humans, CLEC7A rs2087178 A allele and CLEC7A rs2087178A-rs16910631G haplotype is associated with medically-refractory ulcerative colitis (MRUC).