SERPINA1 and cystic fibrosis: Thus, it can be concluded that aerosol preparations of cationic IVT mRNA complexes constitute a potential powerful means to transfect cells in the respiratory tract, including the lung, with the purpose to beneficially modulate the function of such cells in case of diseases such as cystic fibrosis or alpha-1-antitrypsin deficiency, while bringing along the advantages of IVT mRNA as compared to pDNA as transfection agent.