By examining mutation density data of ~3,000 tumor exomes from Kandoth et al. [29], we found that patients having nonsynonymous somatic mutations on any of four genes (FAT4, SYNE1, AHNAK, or COL11A1) often showed a higher cancer genome mutation density at the whole genome level compared to that of wild-type (WT) patients in 4 cancer types: COAD, LUAD, LUSC, and UCEC (Fig 4B). The gene discussed is FAT4; the disease is cancer.