Given first, the inverse association between self-reported allergy, asthma [2], prediagnostic serum IgE [3] and glioma and, second, the fact that glioblastoma-initiating cells inhibit T-cell growth and increase proliferation of immune suppressive regulatory T cells [4], we undertook a study of prediagnostic serum immune function proteins to determine whether they affect glioma risk or would indicate early gliomagenesis. Here, IGHE is linked to central nervous system cancer.