TP53 and urinary bladder cancer: It has been well established that bladder cancer has two defined pathways leading to either superficial low grade bladder tumors or higher grade invasive bladder cancer, and that 50% of invasive bladder tumors harbor mutations/alterations in P53 or P53 pathways.[4, 5] However, emerging reports have highlighted two distinct gene expression profiles even within human iUC which curiously resemble patterns of the basal and luminal subtypes as characterized in human breast cancer.