GABBR1 and Urinary incontinence: It is thought that GABA B receptors have a minor effect on normal relaxation of the striated urethral sphincter and as such we think that in some patients gabapentin may cause incontinence via over relaxation of the external sphincter via excessive influence of GABA B. Physicians administering gabapentin should inform patients about the potential for gabapentin-induced incontinence.