Moreover, 3 of the polymorphisms analyzed in 2 genes (endothelial nitric oxide synthase T786C, interleukin-6 G572C, and interleukin-6 G174C) were found significantly associated with ruptured/ unruptured aneurysms: the endothelial nitric oxide synthase gene SNPs increased the risk, while IL-6 G174C seemed protective. The gene discussed is NOS3; the disease is aneurysm.