Western blotting of LDLRs and PKA/PKG showed that KMUP-1 (10, 20, and 40 μM) could not significantly affect PKA protein expression in HepG2 cells in the presence of LDL (500 μg/ml), a pathologic model of hyperlipidemia, but increased the expression of LDLRs and PKG (Fig. 10B). This evidence concerns the gene PRKG1 and hyperlipidemia.