Stratified analysis on rs2104286 in ACPA-positive and ACPA-negative subgroups showed an HR of 1.82 (95 % CI = 0.88–3.77, p = 0.11) within ACPA-positive RA and an HR of 1.41 (95 % CI = 1.05–1.89, p = 0.024) within ACPA-negative RA (Figure S2B in Additional file 2). The gene discussed is PRTN3; the disease is rheumatoid arthritis.