Combination treatment with HER-1 and HER-2 in EC or HER-1 and IGF-1R in TNBC exhibited increased anti-tumor responses, including reduced proliferation, decreased receptor phosphorylation, increased antibody-dependent cellular cytotoxicity (ADCC) and increased apoptosis in EC (OE19) and TNBC (MDA-MB-231) cell lines. Here, IGF1R is linked to neoplasm.