DNMT3A and neoplasm: The tumor volume was significantly smaller in BGC-shDNMT3A cell-injected nude mice (7.5 ± 9.23 mm3) than in BGC-shControl cell-injected mice (159.5 ± 151.26 mm3; P < 0.05; Fig. 1c and Figure S2b), indicating that DNMT3A has a critical function in tumor growth.