Whereas TDP-43 pathology is reportedly consistent in FTLD and ALS patients with and without the C9ORF72 repeat expansion [9], neuropsychiatric symptoms, as well as cognitive and behavioral impairment, may be more common in FTD and ALS patients that carry the C9ORF72 mutation compared to non-carriers [8, 29]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.