Unlike SMYD3 wild-type, PC4 binding-deficient SMYD3 mutant failed to recover the proliferation and invasiveness of SMYD3-depleted cancer cells (Figure 3D and E), thus demonstrating that SMYD3-mediated recruitment of PC4 is critical for SMYD3 function at genes involved in cell proliferation and invasion. The gene discussed is SMYD3; the disease is cancer.