Several prognosticmarkers in CLL, such as somatic mutations in the immunoglobulin (Ig) heavy chainvariable gene segments (IGHV) (Damle et al.1999; Hamblin et al. 1999), aberrant expression of ZAP-70 (which mayact redundantly with SYK) (Chiorazzi 2012), and upregulation of CCL3 (Sivina et al. 2011), are associated with the function of theBCR, suggesting a relationship between BCR signaling, disease progression, andinferior prognosis. This evidence concerns the gene SYK and B-cell chronic lymphocytic leukemia.