BCR and B-cell chronic lymphocytic leukemia: 2008; Sthoeger et al. 1989). Microbial antigens, such as bacterial andfungal antigens, also can be specifically recognized by CLL BCR. M-CLL patientsexpress IGHV3-7 with short HCDR3 sequences, which display high-affinity binding toβ-(1,6)-glucan, a major antigenic determinant of yeasts and filamentous fungi(Hoogeboom et al. 2013).