It is well recognized that CLL cells inthe proliferative compartment are interspersed with T cells (Ghia et al.2002; Patten et al. 2008) and cells of monocyte/macrophage lineage,termed NLC (Burger et al. 2009).Conceivably, CLL cell-derived CCL3 may attract these cells, creating a favorablemicroenvironment which allows CLL cells to interact with T cells and NLC to receivesurvival and proliferation signals. The gene discussed is CCL3; the disease is B-cell chronic lymphocytic leukemia.