Gene expression profile (GEP)studies revealed that CLL cells from patients with U-CLL show BCR pathway activation(Rosenwald et al. 2001), andcomparative GEP analyses demonstrated that BCR signaling and NF-κB signaling are themost prominent pathways activated in CLL cells isolated from lymphatic tissues(Herishanu et al. 2011), indicatingthat BCR activation is a key driver for CLL proliferation withindisease-characteristic proliferation centers (also called pseudo-follicles) insecondary lymphoid tissues. The gene discussed is BCR; the disease is B-cell chronic lymphocytic leukemia.