CLEC7A and ulcerative colitis: In line with the murine studies, we identified a single-nucleotide polymorphism in human CLEC7A (rs2078178) that significantly associated with ulcerative colitis.8 Moreover, we have found that Dectin-1−/− animals systemically infected with C. albicans have increased GI fungal burdens and dysregulated cytokine production.14 These data therefore suggest that Dectin-1 has a crucial role in protecting the GI tract from fungal-mediated inflammation.