It is possible that the increased T and B-cells apoptosis are interlinked, as B-cell survival can require T-cell help.25 Thus, further investigation is required to understand how loss of Dectin-1 can result in the rapid reduction of mLN cellularity during systemic candidiasis, and how this phenotype relates to the defects in CD4+ T-cell responses. Here, CD4 is linked to candidiasis.