The role of Dectin-1 and other C-type lectin receptors in driving these responses is likely to be important for GI tract homeostasis, as defects in T-cell function within the human and mouse gut, particularly Th17 polarization, is associated with inflammatory bowel disease.15 We therefore examined the role of Dectin-1 in controlling T-cell activation in the GI tract during fungal infection. Here, CLEC4D is linked to fungal infectious disease.