CLEC7A and colitis: C. tropicalis was chosen for these experiments based on recent data, which showed that this species specifically enhanced colitis in Dectin-1−/− mice.8 Exposure of mice to DSS and C. tropicalis induced typical signs of colitis including colon shortening, which was more pronounced in the Dectin-1−/− mice (Supplementary Figure S8a) as we had shown previously.8 In addition, the Dectin-1 KO animals fed on DSS and C. tropicalis had significant reductions in the number of Peyer's patches, which was not observed in WT mice (Figure 6i).