To characterize the role of Dectin-1 in antigen-specific T-cell responses during infection, we made use of the OT.I/OT.II T-cell transgenic system and a previously characterized strain of C. albicans expressing ovalbumin (OVA) peptides (Calb-Ag),19 as there are no T-cell receptor transgenic models specific for C. albicans currently available. This evidence concerns the gene CLEC7A and infection.