Recently, Xu and colleagues reported that a lncRNA FAL1 is overexpressed in some types of cancers including breast cancer, and it interacts with BMI1-PRC1 complex to enhance its stabilization by blocking its proteasomal degradation, which influences the ubiquitylation levels of H2AK119 to epigenetically repress genes expression such as CDKN1A (Neven et al., 2014). The gene discussed is BMI1; the disease is cancer.