Next, we analyzed the effects of N1-guanyl-1,7-diaminoheptane (GC7), a hypusination inhibitor that blocks deoxyhypusine synthase (DHS) function, and the anti-eIF5A neutralizing mAbs in a rat model of myocardial ischemia/reperfusion. The gene discussed is EIF5A; the disease is myocardial ischemia.