Recent experimental and epidemiological studies suggested that ANRIL, VAMP3 and PLASMINOGEN are involved in several regulatory networks that relate to glucose and fatty acid metabolism, host-microbiome interactions and TGF-β signaling, providing evidence for a mechanistic link between ACVD, periodontitis, obesity and inflammation [27–30]. Here, TGFB1 is linked to obesity due to melanocortin 4 receptor deficiency.