Our results show that a simplified HIV test and treat intervention incorporating a streamlined, standardized time frame for diagnosis and expanded access to ART, irrespective of CD4 cell count, resulted in a significant increase in ART coverage within 90 d of diagnosis of HIV infection, from below 36% to over 90% among all newly diagnosed HIV/AIDS cases, and from under 47% to over 93% among newly diagnosed cases with CD4 count ≤ 350 cells/mm3 or missing CD4 but reported as AIDS cases. This evidence concerns the gene CD4 and HIV infectious disease.