LRP5 mutation p.Thr173Met, identified in one isolated HBM case, was previously reported in association with abnormal retinal vasculature/folds in an older British woman diagnosed with familial exudative vitreoretinopathy (FEVR); however, her BMD was not reported.50 Although SIFT and PMut consider this mutation to be tolerated/neutral, respectively, PolyPhen and Mutation Taster predict it to be “probably damaging” and “disease causing,” with a moderate conservation score (GERP 1.67, Table 1). This evidence concerns the gene LRP5 and exudative vitreoretinopathy.