Formation of the receptor/β-arrestin-1/SRC (or SRC family member HCK, FGR or YES) ternary complexes has been demonstrated to regulate multiple cellular functions downstream of various receptors, including, but not limited to, anti-apoptotic effects, granule exocytosis, colorectal carcinoma cell migration, bacterial adhesion to endothelial cells and the proliferation of pancreatic β-cells26, 27, 28, 29, 30, 31. The gene discussed is YES1; the disease is colorectal carcinoma.