Here, TLR2 and TLR4 expression on MDMs exposed to LAM were analyzed during differentiation and observation showed that when monocytes were exposed to LAM for 96 h, the frequency of TLR2+ macrophages was reduced compared to both monocytes and macrophages that had never been in contact with LAM (Figure 6(b)). Here, TLR4 is linked to lymphangioleiomyomatosis.