CDH1 and diabetes mellitus: In the present study, we found that the expression of α-SMA was significantly decreased, accompanied by increased expression of E-cadherin in TGT-treated DM rats in a dose-dependent matter, but not in untreated DM rats, suggesting that the inhibition of EMT could be an important mechanism by which TGT exerts its effectiveness on renal tubulointerstitial fibrosis.