Finally, our diverse analyses allowed us to provide potential thresholds to discriminate periodontitis (i.e., IL-1ß: 24–28 pg/mL; IL-6: 5.11–5.5 pg/mL; MIP-1α: 3.28–5 pg/mL, and MMP-8: 140–165.9 ng/mL). The gene discussed is MMP8; the disease is periodontitis.