PhIP increased the number of small intestinal tumors in ob/ob mice (P < 0.001), in ob/wt mice (P < 0.001) and in wt/wt mice (P < 0.001), and in both females (P < 0.001, for all three comparisons) and males (P < 0.001, for all three comparisons) of each ob genotype (Figure 2). The gene discussed is PHIP; the disease is small intestine neoplasm.