In a previous study, similar results as in our study were found by crossing a mouse with a different mutation in the Apc gene (Apc1638N/+) with the C57BLKS-mLepdb/db mice, carrying a mutation in the leptin receptor gene (Ob-Rb) causing both obesity and diabetes mellitus [26]. The gene discussed is LEPR; the disease is obesity due to melanocortin 4 receptor deficiency.