APC and intestinal neoplasm: Except for the female and male Apc+/+ X ob/wt given 0.9% NaCl and 45% fat diet, and the male Apc+/+ X wt/wt given PhIP and 45% fat diet, slightly lower body weight can be explained by the fact that ApcMin/+ mice generally have lower body weight than the Apc+/+ because of their spontaneous intestinal tumors, affected even further with PhIP [19].