NR3C1 and urinary bladder carcinoma: It has been shown that GRα can directly function as a corepressor of NF-κB. Additionally, the synthetic glucocorticoid dexamethasone inactivates NF-κB and downregulates NF-κB-dependent cytokine IL-6, which may be a central mechanism involved in GR-mediated inhibition of bladder cancer cell invasion [69].