Interestingly, MIF, which is secreted in response to hypoxia by different tumor cells, was reported to induce CD11b+GR1+ myeloid cell migration via CD74/CXCR4 and CD74/CXCR2 complexes, as well as through p38 and PI3K activation (167). The gene discussed is CXCR4; the disease is neoplasm.