For example, blocking the CXCL12/CXCR4 axis with the CXCR4 antagonist AMD3100 or Plerixafor is clinically approved for the mobilization of hematopoietic progenitor cells in combination with granulocyte-colony stimulating factor (G-CSF) in patients with non-Hodgkin’s lymphoma and multiple myeloma (2). The gene discussed is CXCR4; the disease is plasma cell myeloma.