Given that HIV-1 infection induces COX-2 in multiple cell types (52, 53), we examined COX-2 mRNA in TZMbl-2 cells exposed to HIV-1 proteins (p17, p24, gp1, and gp120), positive control (Pam3CSK4), and negative control (medium). The gene discussed is ITIH4; the disease is HIV-1 infection.