ITGA2B and asthma: Indeed, P2X7R signaling on DCs is involved in the sensitization phase of allergic disorders such as contact hypersensitivity (through CD81 T-cell priming) (57) and asthma (through CD41 T-cells, TH2 response) (58), and contributes to transplant rejection (through CD41 T cells, TH1 response) (59).