Another study shows that oligomeric hyaluronan of 6–40 saccharides, which is frequently found in tumor-bearing patients, enhances cleavage of the hyaluronan receptor CD44 in malignant tumor cells, and concomitantly upregulates CD44-dependent tumor cell migration, whereas larger polymers of hyaluronan fail to enhance CD44 cleavage and migration (24). This evidence concerns the gene CD44 and neoplasm.