SNPs in the GNAI2 gene are associated with increased hypertension risk in Caucasian Italians and in the Millennium Genome Project for Hypertension in Japan (Menzaghi et al., 2006; Kohara et al., 2008), providing the first evidence of the potential utility of GNAI2 SNPs as a biomarker of hypertension risk. This evidence concerns the gene GNAI2 and hypertensive disorder.