It is generally less abundantly expressed than the major isoforms NDPK-A and NDPK-B (Erent et al., 2001), but it is highly enriched at the cardiac plasma membrane of patients with end-stage HF and its content in these preparations reached the levels of NDPK-A and NDPK-B (Lutz et al., 2004; Abu-Taha et al., 2013). Here, NME1 is linked to hydrops fetalis.