As SK4–/–-mice are protected from developing severe colitis in mouse models of inflammatory bowel disease (Di et al., 2010a) and CD4-positive T-lymphocytes from NDPKB–/–- and SK4–/–-mice show similar profiles of cytokine production (Di et al., 2010a,b), it is very likely that the constitutive activation of SK4-channels is also required for inflammatory responses. Here, KCNN4 is linked to inflammatory bowel disease.