HMOX1 and Hypertension: HO-1 induction has been shown to be protective and anti-hypertensive in several experimental models of hypertension, including the reduced uterine perfusion pressure (RUPP) model, known to be associated with elevated TNF-α levels (Sabaawy et al., 2001; Yang et al., 2004; Botros et al., 2005; George et al., 2011b).