KCNA1 and episodic ataxia type 1: EA1 mutations drastically alter the function of heteromeric channels composed of Kv1.1, Kv1.2, Kv1.4 and Kvβ1.1 subunits and may therefore, contribute to seizure susceptibility and cognitive symptoms in EA1 (Imbrici et al., 2006, 2011).