A recent study using an inducible KrasG12D model of PDA demonstrated loss of FDG uptake and a decrease in glucose uptake and lactate secretion following loss of KrasG12D expression.28 This study also showed a decrease in expression of the glucose transporter GLUT1 and in the hexokinases HK1 and HK2. This evidence concerns the gene HK2 and Patent ductus arteriosus.