Our previous analyses of chronic AngII infusion with accompanying hypertension demonstrated that a new homeostatic state was achieved that balanced AngII stimulation of Na+ transporters from the cortical TALH to the collecting duct with hypertension-driven compensatory inhibition of Na+ transporters along the proximal tubule and medullary TALH, resulting in effective circulating volume homeostasis at normal levels. The gene discussed is AGT; the disease is Hypertension.