AGT and hypertensive disorder: 2003). These findings are consistent with stimulatory concentrations of renal AngII at subpressor infusion doses (200–400 ng/kg/min) from 3 days to 2 weeks. These AngII doses are expected to stimulate sodium transporters, thus, impair pressure natriuresis and eventually provoke hypertension, renal injury, and intrarenal production of AngII (McDonough and Nguyen 2015).