In this study, we asked whether short-term subpressor low-dose AngII without counteracting hypertension would stimulate proximal and TALH transporters including NHE3 and NKCC2, and asked whether this low-dose AngII would also stimulate distal transporters, including cortical NKCC, NCC, and ENaC without the augmented intrarenal RAS activation observed during 2-week AngII infusion. The gene discussed is SLC12A1; the disease is hypertensive disorder.