SLC12A3 and Hypertension: 1996). Elevated sodium transporters from the cTALH to the CD likely play a role in the ultimate development of hypertension seen at higher doses and longer infusion times. After 2 weeks of 400 ng/kg/min AngII infusion with accompanying hypertension, no further increases in NKCC, NKCC-P, ENaC α or β subunits were evident, however, there further increases in NCC, NCC-P, αENaC cleavage, and γENaC cleavage were evident (Fig. 7) that could be attributed to intrarenal AngII production, aldosterone activation, or accompanying inflammation and injury.