1996). Elevated sodium transporters from the cTALH to the CD likely play a role in the ultimate development of hypertension seen at higher doses and longer infusion times. After 2 weeks of 400 ng/kg/min AngII infusion with accompanying hypertension, no further increases in NKCC, NKCC-P, ENaC α or β subunits were evident, however, there further increases in NCC, NCC-P, αENaC cleavage, and γENaC cleavage were evident (Fig. 7) that could be attributed to intrarenal AngII production, aldosterone activation, or accompanying inflammation and injury. This evidence concerns the gene SLC5A4 and Hypertension.