SLC12A3 and hypertensive disorder: These studies have informed us that the responses of sodium transporters to acute AngII are distinct from the responses to chronic AngII: acutely, both proximal tubule NHE3 and distal tubule NCC redistribute into domains of apical membranes where they are active (without changes in abundance or phosphorylation); during chronic AngII infusion, with accompanying hypertension, the abundance of proximal NHE3 in the apical membrane is depressed, whereas abundance and phosphorylation of distal NCC in apical membranes is increased.