2003). These findings are consistent with stimulatory concentrations of renal AngII at subpressor infusion doses (200–400 ng/kg/min) from 3 days to 2 weeks. These AngII doses are expected to stimulate sodium transporters, thus, impair pressure natriuresis and eventually provoke hypertension, renal injury, and intrarenal production of AngII (McDonough and Nguyen 2015). The gene discussed is SLC5A4; the disease is hypertensive disorder.