Altered KvDMR-ICR2 methylation, as observed within this study, may influence breast cancer risk through an effect on CDKN1C or KCNQ1OT1. Further work on the links between KvDMR-ICR2 methylation and CDKN1C/KCNQ1OT1 gene expression in cancer would be instructive. Here, KCNQ1OT1 is linked to breast cancer.