TGFBR2 and neoplasm: In the top 10 potential related miRNAs, mir-34 family (a and b), which functions as tumor-suppressive miRNAs to induce apoptosis and inhibit proliferation in lung cancer cells by directly targeting TGFβR2 and Met, are inactivated by CpG methylation at their promoter region96, 97, 98, 99, 100, 101, 102, 103; Also, mir-218, 133a and 143 are tumor-suppressors that play roles in inhibiting tumor cell invasion by targeting the tumorigenesis-related genes in lung cancer, such as N-cadherin, oncogenic receptors and so on104, 105, 106, 107, 108, 109, 110, 111, 112, 113.