In this work, we focused on knowledge cliffs next to some of the most-established interactions such as BACE1-APP and found four “potential new candidates”, namely TP53INP2, RTN4, F2RL3, and FBXO2, presumably new targets for Alzheimer’s disease as guided by the knowledge cliff concept. Here, F2RL3 is linked to early-onset autosomal dominant Alzheimer disease.