Our results revealed a consistent pattern: DYRK1BL28P (found in rare cases of metabolic syndrome as well as cancer) exhibited identical kinase activity to wild-type DYRK1B; DYRK1BR102H and DYRK1BS234G exhibited 40–50 % reduction in kinase activity and DYRK1BQ275R exhibited a 90 % reduction in kinase activity (Fig. 8a). The gene discussed is DYRK1B; the disease is cancer.