In this study high CD3/c-kit, high CD3/VEGF, and high c-kit/VEGF tumors were statistically associated with elevated grade of malignancy (P < 0.0001 for CD3/c-kit, CD3/VEGF, and c-kit/VEGF), presence of neoplastic intravascular emboli (P < 0.0001 for CD3/c-kit and CD3/VEGF; P = 0.002 for c-kit/VEGF), and presence of lymph node metastasis (P < 0.0001 for CD3/c-kit, CD3/VEGF, and c-kit/VEGF). Here, KIT is linked to metastatic malignant neoplasm in the lymph nodes.