Indeed, AQP3 plays a pivotal role in the regulation of glycerol-related metabolism in the epidermis; therefore, AQP3 inhibition has been proposed as new therapeutic strategy in many hyperproliferative skin disorders (see Table 1) such as psoriasis, atopic dermatitis, and skin carcinogenesis [45, 63, 64]. This evidence concerns the gene AQP3 and skin disorder.