CFL1 and neoplasm: For Cofilin, it has been reported that angiogenesis inhibitors such as Endostatin, thrombospondin-1, fumagillin, endothelial monocyte activating polypeptide II, and TNP-470 alter the phosphorylation state of Cofilin and induce formation of stress fibers in endothelial cells, which might have an impact on tumor-induced neovascularization and blood supply [129].