WAVE2 is strongly expressed in colorectal carcinoma cells, but only weakly in colonic epithelium maintaining normal structure; furthermore, colocalization of Arp2 and WAVE2 is associated with tumor cell budding, an established marker for aggressive tumor behavior in colorectal carcinoma and an independent risk factor for liver metastasis in CRC [30, 56]. Here, ACTR2 is linked to colorectal carcinoma.