We have shown, for example, that KRAS mutation status and an inflammatory response have an impact on Abi1 expression levels in CRC cells [96]; taking this into account, the mere expression of actin-binding proteins does not necessarily imply a more aggressive tumor behavior, all the more since most of these proteins are subject to phosphorylation and dephosphorylation events with great impact on their respective activity. Here, ABI1 is linked to colorectal carcinoma.