ARPC1A, the gene encoding for the p41 subunit of Arp2/3, is frequently overexpressed in pancreatic cancer due to 7q21-q22 gene amplification, and RNA interference experiments show a significant decrease in tumor cell migration and invasion upon ARPC1A and ARPC4 knockdown [31, 32]. This evidence concerns the gene ARPC1A and familial pancreatic carcinoma.