Finally, a tumor-promoting role for Calreticulin has been shown to be linked to dysregulation of Cortactin expression, and vascular endothelial growth factor C (VEGF-C) contributes to tumor growth and metastasis via Src-miR326-mediated overexpression of Cortactin in ESCC [70, 71]. This evidence concerns the gene VEGFC and esophageal squamous cell carcinoma.