NRF1 and brain ischemia: Interestingly, Kuo et al. [18] and Liu et al. [19] found that the curcumin treatment normalized the mitochondrial biogenesis altered in a liver steatosis obese mice model and a cerebral ischemia reperfusion rat model, respectively, as markers like nuclear respiratory factor 1 (NRF1) and mitochondrial transcription factor A (Tfam) were preserved after the treatment.