TGM2 and irritable bowel syndrome: Based on the international guidelines, published data, and our own clinical experience, we believe that all referred IBS patients should be tested for CD with serologic testing, including a combination of tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP) antibodies, which have demonstrated a high sensitivity and specificity [50], and when there is doubt, duodenal biopsy samples should be taken.