Mir-146a potentially interacts with genes which are involved in cardiovascular diseases too as ABL2, that mediate vascular permeability, and EDNRB gene providing instructions for making a protein called endothelin receptor type B. Endothelins regulate several critical biological processes, including the development and function of blood vessels, Regarding Endocrine system regulation, in particular, hsa-mir-146a has complementary sequence for 3′-UTR region of endocrine system genes as MED1, which has been shown may interact with Androgen receptor, Estrogen receptor alpha, and p53. The gene discussed is ESR1; the disease is cardiovascular disorder.