Mir-146a potentially interacts with genes which are involved in cardiovascular diseases too as ABL2, that mediate vascular permeability, and EDNRB gene providing instructions for making a protein called endothelin receptor type B. Endothelins regulate several critical biological processes, including the development and function of blood vessels, Regarding Endocrine system regulation, in particular, hsa-mir-146a has complementary sequence for 3′-UTR region of endocrine system genes as MED1, which has been shown may interact with Androgen receptor, Estrogen receptor alpha, and p53. This evidence concerns the gene MED1 and cardiovascular disorder.