EPHA4 and neoplasm: Western blot analysis of tumor tissue harvested from EphA4−/−EphA7−/−Smo, EphA4+/−EphA7−/−Smo, and EphA4+/+EphA7−/−Smo mice revealed expression of p-Akt (Fig. 4a, b) and PCNA (Fig. 4a, c) that correlated with actual tumor size.