And overexpression of miRNA-497 inhibited the survival of 4T1 breast cancer cells via targeting VEGFR2 and its downstream signal pathway proteins Bcl-2 and Bax expression (see Supplementary material online, Fig. S4B–D), which markedly increased 4T1 breast cancer cells apoptosis (see Supplementary material online, Fig. S4E–F). Here, BAX is linked to breast cancer.