And overexpression of miRNA-497 inhibited the survival of 4T1 breast cancer cells via targeting VEGFR2 and its downstream signal pathway proteins Bcl-2 and Bax expression (see Supplementary material online, Fig. S4B–D), which markedly increased 4T1 breast cancer cells apoptosis (see Supplementary material online, Fig. S4E–F). This evidence concerns the gene KDR and breast carcinoma.